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Miruna-Silvia Stan     Post Doctoral Researcher 
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Miruna-Silvia Stan published an article in March 2019.
Research Keywords & Expertise See all
0 A
0 Apoptosis
0 Nanoparticles
0 Oxidative Stress
0 Quantum Dots
0 Glutathione
Top co-authors See all
Marieta Costache

89 shared publications

Department of Biochemistry and Molecular Biology, University of Bucharest, Bucharest 050095, Romania

Anca Dinischiotu

54 shared publications

Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Bucharest, 91-95 Splaiul Independentei, 050095, Bucharest, Romania

Anca Hermenean

42 shared publications

Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Bucharest, 91-95 Splaiul Independentei, 050095 Bucharest, Romania

Elena Codrici

23 shared publications

Victor Babes National Institute of Pathology, 050096 Bucharest, Romania

Aurel Ardelean

14 shared publications

Institute of Life Sciences, Vasile Goldis Western University of Arad, Arad, Romania

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Publication Record
Distribution of Articles published per year 
(2012 - 2019)
Total number of journals
published in
 
12
 
Publications See all
Article 0 Reads 0 Citations Amorphous Silica Nanoparticles Obtained by Laser Ablation Induce Inflammatory Response in Human Lung Fibroblasts Sorina Nicoleta Voicu, Mihaela Balas, Miruna Silvia Stan, Bo... Published: 28 March 2019
Materials, doi: 10.3390/ma12071026
DOI See at publisher website ABS Show/hide abstract
Silica nanoparticles (SiO2 NPs) represent environmentally born nanomaterials that are used in multiple biomedical applications. Our aim was to study the amorphous SiO2 NP-induced inflammatory response in MRC-5 human lung fibroblasts up to 72 hours of exposure. The intracellular distribution of SiO2 NPs was measured by transmission electron microscopy (TEM). The lactate dehydrogenase (LDH) test was used for cellular viability evaluation. We have also investigated the lysosomes formation, protein expression of interleukins (IL-1β, IL-2, IL-6, IL-8, and IL-18), COX-2, Nrf2, TNF-α, and nitric oxide (NO) production. Our results showed that the level of lysosomes increased in time after exposure to the SiO2 NPs. The expressions of interleukins and COX-2 were upregulated, whereas the expressions and activities of MMP-2 and MMP-9 decreased in a time-dependent manner. Our findings demonstrated that the exposure of MRC-5 cells to 62.5 µg/mL of SiO2 NPs induced an inflammatory response.
Article 0 Reads 0 Citations Characterization of Nanoparticle Intestinal Transport Using an In Vitro Co-Culture Model Alina F.G. Strugari, Miruna S. Stan, Sami Gharbia, Anca Herm... Published: 21 December 2018
Nanomaterials, doi: 10.3390/nano9010005
DOI See at publisher website PubMed View at PubMed ABS Show/hide abstract
We aimed to obtain a tunable intestinal model and study the transport of different types of nanoparticles. Caco-2/HT29-MTX co-cultures of different seeding ratios (7:3 and 5:5), cultured on Transwell® systems, were exposed to non-cytotoxic concentration levels (20 μg/mL) of silicon quantum dots and iron oxide (α-Fe2O3) nanoparticles. Transepithelial electric resistance was measured before and after exposure, and permeability was assessed via the paracellular marker Lucifer Yellow. At regular intervals during the 3 h transport study, samples were collected from the basolateral compartments for the detection and quantitative testing of nanoparticles. Cell morphology characterization was done using phalloidin-FITC/DAPI labeling, and Alcian Blue/eosin staining was performed on insert cross-sections in order to compare the intestinal models and evaluate the production of mucins. Morphological alterations of the Caco-2/HT29-MTX (7:3 ratio) co-cultures were observed at the end of the transport study compared with the controls. The nanoparticle suspensions tested did not diffuse across the intestinal model and were not detected in the receiving compartments, probably due to their tendency to precipitate at the monolayer surface level and form visible aggregates. These preliminary results indicate the need for further nanoparticle functionalization in order to appropriately assess intestinal absorption in vitro.
Article 0 Reads 0 Citations Zinc Oxide Spherical-Shaped Nanostructures: Investigation of Surface Reactivity and Interactions with Microbial and Mamm... Diana Beatrice Visinescu, Mohammed Dyia Hussien, Jose Maria ... Published: 19 October 2018
Langmuir, doi: 10.1021/acs.langmuir.8b02528
DOI See at publisher website
Article 1 Read 0 Citations Designing cotton fibers impregnated with photocatalytic graphene oxide/Fe, N-doped TiO2 particles as prospective industr... Miruna Silvia Stan, Madalina Andreea Badea, Gratiela G. Pirc... Published: 18 September 2018
Materials Science and Engineering: C, doi: 10.1016/j.msec.2018.09.046
DOI See at publisher website PubMed View at PubMed
Article 0 Reads 0 Citations Reduced graphene oxide/TiO2 nanocomposites coating of cotton fabrics with antibacterial and self-cleaning properties Miruna S Stan, Ionela C Nica, Marcela Popa, Mariana C Chifir... Published: 24 May 2018
Journal of Industrial Textiles, doi: 10.1177/1528083718779447
DOI See at publisher website
BOOK-CHAPTER 0 Reads 0 Citations Biomedical applications of carbon nanotubes with improved properties Miruna S. Stan, Alina F.G. Strugari, Mihaela Balas, Ionela C... Published: 01 January 2018
Fullerens, Graphenes and Nanotubes, doi: 10.1016/b978-0-12-813691-1.00002-6
DOI See at publisher website
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