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Miruna-Silvia Stan     Post Doctoral Researcher 
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Miruna-Silvia Stan published an article in October 2018.
Research Keywords & Expertise See all
0 A
0 Apoptosis
0 Nanoparticles
0 Oxidative Stress
0 Quantum Dots
0 Glutathione
Top co-authors See all
Marieta Costache

87 shared publications

Department of Biochemistry and Molecular Biology, University of Bucharest, Bucharest 050095, Romania

Anca Dinischiotu

60 shared publications

Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Bucharest, 91-95 Splaiul Independentei, 050095, Bucharest, Romania

Anca Hermenean

46 shared publications

Institute of Life Sciences; Vasile Goldis Western University of Arad; Arad Romania

Elena Codrici

25 shared publications

Department of Biochemistry‑Proteomics, ‘Victor Babes’ National Institute of Pathology, 050096 Bucharest, Romania

Aurel Ardelean

20 shared publications

Department of Experimental and Applied Biology, Institute of Life Sciences, Vasile Goldis Western University of Arad, 310414 Arad, Romania

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Publication Record
Distribution of Articles published per year 
(2012 - 2018)
Total number of journals
published in
 
9
 
Publications See all
Article 0 Reads 0 Citations Zinc Oxide Spherical-Shaped Nanostructures: Investigation of Surface Reactivity and Interactions with Microbial and Mamm... Diana Beatrice Visinescu, Mohammed Dyia Hussien, Jose Maria ... Published: 19 October 2018
Langmuir, doi: 10.1021/acs.langmuir.8b02528
DOI See at publisher website
Article 0 Reads 0 Citations Enhancement of Silymarin Anti-fibrotic Effects by Complexation With Hydroxypropyl (HPBCD) and Randomly Methylated (RAMEB... Sami Gharbia, Cornel Balta, Hildegard Herman, Marcel Rosu, J... Published: 13 August 2018
Frontiers in Pharmacology, doi: 10.3389/fphar.2018.00883
DOI See at publisher website ABS Show/hide abstract
Silymarin (Sy) shows limited water solubility and poor oral bioavailability. Water-soluble hydroxypropyl (HPBCD) and randomly methylated (RAMEB) β-cyclodextrins were designed to enhance anti-fibrotic efficiency of silymarin in CCl4-induced liver fibrosis in mice. Experimental fibrosis was induced by intraperitoneal injection with 2 ml/kg CCl4 (20% v/v) twice a week, for 7 weeks. Mice were orally treated with 50 mg/kg of Sy-HPBCD, Sy-RAMEB and free silymarin. For assessment of the spontaneous reversion of fibrosis, CCl4 treated animals were investigated after 2 weeks of recovery time. The CCl4 administration increased hepatic oxidative stress, augmented the expression of transforming growth factor-β1 (TGF-β1) and Smad 2/3, and decreased Smad 7 expression. Furthermore, increased α-smooth muscle actin (α-SMA) expression indicated activation of hepatic stellate cells (HSCs), while up-regulation of collagen I (Col I) and matrix metalloproteinases (MMPs) expression led to an altered extracellular matrix enriched in collagen, confirmed as well by trichrome staining and electron microscopy analysis. Treatment with Sy-HPBCD and Sy-RAMEB significantly reduced liver injury, attenuating oxidative stress, restoring antioxidant balance in the hepatic tissue, and significantly decreasing collagen deposits in the liver. The levels of pro-fibrogenic markers’ expression were also significantly down-regulated, whereas in the group for spontaneous regression of fibrosis, they remained significantly higher, even at 2 weeks after CCl4 administration was discontinued. The recovery was significantly lower for free silymarin group compared to silymarin/β cyclodextrins co-treatments. Sy-HPBCD was found to be the most potent anti-fibrotic complex. We demonstrated that Sy-HPBCD and Sy-RAMEB complexes decreased extracellular matrix accumulation by inhibiting HSC activation and diminished the oxidative damage. This might occur via the inhibition of TGF-β1/Smad signal transduction and MMP/tissue inhibitor of MMPs (TIMP) rebalance, by blocking the synthesis of Col I and decreasing collagen deposition. These results suggest that complexation of silymarin with HPBCD or RAMEB represent viable options for the its oral delivery, of the flavonoid as a potential therapeutic entity candidate, with applications in the treatment of liver fibrosis.
Article 0 Reads 0 Citations Reduced graphene oxide/TiO2 nanocomposites coating of cotton fabrics with antibacterial and self-cleaning properties Miruna S Stan, Ionela C Nica, Marcela Popa, Mariana C Chifir... Published: 24 May 2018
Journal of Industrial Textiles, doi: 10.1177/1528083718779447
DOI See at publisher website
BOOK-CHAPTER 0 Reads 0 Citations Biomedical applications of carbon nanotubes with improved properties Miruna S. Stan, Alina F.G. Strugari, Mihaela Balas, Ionela C... Published: 01 January 2018
Fullerens, Graphenes and Nanotubes, doi: 10.1016/b978-0-12-813691-1.00002-6
DOI See at publisher website
BOOK-CHAPTER 1 Read 0 Citations List of Contributors Chinmayee Acharya, Sohail Akhter, Pramod K. Avti, Emanuel Ax... Published: 01 January 2018
Fullerens, Graphenes and Nanotubes, doi: 10.1016/b978-0-12-813691-1.00022-1
DOI See at publisher website
Article 0 Reads 0 Citations Enhance stability and in vitro cell response to a bioinspired coating on zr alloy with increasing chitosan content Daniela Ionita, Maria Vardaki, Miruna S. Stan, Anca Dinischi... Published: 01 September 2017
Journal of Bionic Engineering, doi: 10.1016/s1672-6529(16)60411-0
DOI See at publisher website
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