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Darinka Christova   Professor  Institute, Department or Faculty Head 
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Darinka Christova published an article in May 2014.
Top co-authors
Bistra Kostova

14 shared publications

Department of Pharmaceutical Technology and Biopharmaceutics, Faculty of Pharmacy; Medical University of Sofia; Sofia 1000 Bulgaria

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Article 0 Reads 2 Citations Evaluation of Poly(2-Ethyl-2-Oxazoline) Containing Copolymer Networks of Varied Composition as Sustained Metoprolol Tart... Bistra Kostova, Sijka Ivanova, Konstantin Balashev, Dimitar ... Published: 03 May 2014
AAPS PharmSciTech, doi: 10.1208/s12249-014-0120-0
DOI See at publisher website PubMed View at PubMed ABS Show/hide abstract
Segmented copolymer networks (SCN) based on poly(2-ethyl-2-oxazoline) and containing 2-hydroxyethyl methacrylate, 2-hydroxypropyl acrylate, and/or methyl methacrylate segments have been evaluated as potential sustained release systems of the water soluble cardioselective β-blocker metoprolol tartrate. The structure and properties of the drug carriers were investigated by differential scanning calorimetry, attenuated total reflectance Fourier transform infrared spectroscopy, scanning electron microscopy, and atomic force microscopy. Swelling kinetics of SCNs in various media was followed, and the conditions for effective MT loading were specified. MT-loaded SCNs with drug content up to 80 wt.% were produced. The release kinetics of metoprolol tartrate from the systems was studied and it was shown that the conetworks of different structure and composition are able to sustain the metoprolol tartrate release without additional excipients.
Article 0 Reads 6 Citations Study of the Potential of Amphiphilic Conetworks Based on Poly(2-ethyl-2-oxazoline) as New Platforms for Delivery of Dru... Bistra Kostova, Krasimira Ivanova-Mileva, Dimitar Rachev, Da... Published: 17 January 2013
AAPS PharmSciTech, doi: 10.1208/s12249-013-9923-7
DOI See at publisher website PubMed View at PubMed ABS Show/hide abstract
Thermoresponsive amphiphilic conetworks comprising poly(2-ethyl-2-oxazoline) (PEtOx), 2-hydroxyethyl methacrylate, and 2-hydroxypropyl acrylate segments have been studied as new platforms for delivery of drug with limited solubility. Series of conetworks of varied composition were synthesized and swelling kinetics in aqueous media and ethanol were followed. The platforms were loaded with the hydrophobic drug ibuprofen by swelling in its ethanol solution. The structure and properties of the drug carriers were investigated by scanning electron microscopy and differential scanning calorimetry. The release kinetics profiles of ibuprofen from the studied platform were established. The investigation proved the feasibility of the PEtOx-based amphiphilic conetworks as highly effective platforms for sustained ibuprofen delivery.